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Stability of theophylline elimination rate

✍ Scribed by Milavetz, Gary; Vaughan, Leigh M; Weinberger, Miles M


Book ID
109844253
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
315 KB
Volume
41
Category
Article
ISSN
0009-9236

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The effect of erythromycin stearate at a dose of 1 g daily on theophylline disposition was studied in six healthy adult males. The mean value of 5.46 h for the theophylline half-life after 48 h pretreatment with erythromycin stearate was not significantly different from the control value of 5.24 h.

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The disposition of theophylline was studied on four occasions in eight healthy adult males. The control mean theophylline half-life and clearance were 7.32 h and 086 ml min-Ikg-', respectively. After 5 days pretreatment with placebo the corresponding values of 7.01 and 0-88 were not significantly di