Stability of theophylline elimination rate
β Scribed by Milavetz, Gary; Vaughan, Leigh M; Weinberger, Miles M
- Book ID
- 109844253
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 315 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0009-9236
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π SIMILAR VOLUMES
The effect of erythromycin stearate at a dose of 1 g daily on theophylline disposition was studied in six healthy adult males. The mean value of 5.46 h for the theophylline half-life after 48 h pretreatment with erythromycin stearate was not significantly different from the control value of 5.24 h.
The disposition of theophylline was studied on four occasions in eight healthy adult males. The control mean theophylline half-life and clearance were 7.32 h and 086 ml min-Ikg-', respectively. After 5 days pretreatment with placebo the corresponding values of 7.01 and 0-88 were not significantly di