Stability of salicylic acid and cetrimide system in the presence of additives

✍ Scribed by Lucy S. C. Wan

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 461 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600633

✦ Synopsis

Various additives were added to the gel-like product which results from the interaction of salicylic acid with cetrimide. The additives were alcohols, acetone, water, glycerin, propylene glycol, polyethylene glycols, amyl acetate, heptane, hexadecane, dioxane, cyclohexane, benzene, methylbenzene, ethylbenzene, nitrobenzene, pyridine, tetralin, carbon tetrachloride, chloroform, liquefied phenol BP, and cresol BP. The first 10 compounds reduced the viscosity of the gel-like product to varying degrees, and the reduction generally increased with an increasing volume of the additive. The remaining 11 compounds together with the higher alcohols, from hexyl to decyl alcohol, increased the viscosity initially, followed soon after by a viscosity decrease. The instability of the system in the presence of the additives was probably due largely to their effect on the links in the network structure of the macromolecules which formed the gel-like product. The initial rise in viscosity could be due to a tendency of a small amount of the additive to bring the macromolecules closer together, thus making the system more viscous. The fall after this rise could be attributed to the breakup of the mesh with larger amounts of the additive and possibly to a change in the nature of the system.

Keyphrases 0 Salicylic acid-cetrimide system-stability in presence of additives 0 Cetrimide-salicylic acid interaction, stabilityeffect of additives 0 Additives-effect on stability of salicylic acid-cetrimide system 0 Viscosity-effect of additives on salicylic acid-cetrimide interaction