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Stability of high cell density brewery fermentations during serial repitching

โœ Scribed by Pieter J. Verbelen; Tinne M. L. Dekoninck; Sebastiaan E. Van Mulders; Sofie M. G. Saerens; Filip Delvaux; Freddy R. Delvaux


Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
366 KB
Volume
31
Category
Article
ISSN
0141-5492

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High cell density induces spontaneous bi
โœ John D. Chung; Conway C. Chang; James Ashley Groves ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 246 KB

High cell density cultures of CHO cells growing in a bioreactor under dissolved oxygen control were found to undergo spontaneous bifurcations and a subsequent loss of stability some time into the fermentation. This loss of stability was manifested by sustained and amplified oscillations in the biore