Stability of diltiazem and its metabolites in human blood samples
β Scribed by Jean-Louis Bonnefous; Roselyne Boulieu; Christiane Lahet
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 357 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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KEY WORDS Diltiazem Stability Plasma HPLC assay INTRODUCTION Diltiazem is a calcium antagonist which is currently used in the treatment of angina pectoris, hypertension, and supraventricular arrhythmias.'-4 At present, in our laboratory, diltiazem and six of its metabolites have been identified and
The pharmacokinetics of oral diltiazem were studied in 10 patients with chronic renal failure not requiring dialysis and in five healthy volunteers after a single dose of 120mg. We found that patients with chronic renal failure had lower amounts of unchanged diltiazem and of its main metabolite (MA)