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Stability of diltiazem and its metabolites in human blood samples

✍ Scribed by Jean-Louis Bonnefous; Roselyne Boulieu; Christiane Lahet


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
357 KB
Volume
81
Category
Article
ISSN
0022-3549

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KEY WORDS Diltiazem Stability Plasma HPLC assay INTRODUCTION Diltiazem is a calcium antagonist which is currently used in the treatment of angina pectoris, hypertension, and supraventricular arrhythmias.'-4 At present, in our laboratory, diltiazem and six of its metabolites have been identified and

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The pharmacokinetics of oral diltiazem were studied in 10 patients with chronic renal failure not requiring dialysis and in five healthy volunteers after a single dose of 120mg. We found that patients with chronic renal failure had lower amounts of unchanged diltiazem and of its main metabolite (MA)