Stability of certified dyes in tablets II. Fading of FD&C Red No. 3 and FD&C Red No. 3 aluminum lake in three tablet formulas

✍ Scribed by F. W. Goodhart; M. E. Everhard; D. A. Dickcius

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 280 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530323

✦ Synopsis

T h e fading rates of FD&C Red No. 3 and its aluminum lake were determined in three tablet formulas which differed only in the excipient employed. In tablets of calcium sulfate the dye faded at about twice the rate of the same dye in either dicalcium phosphate or lactose tablets. However, the use of the corresponding lake in the calcium sulfate formulation reduced the fading rate si nificantly. N o significant differences in fading rates were demonstrated between $e dye and the lake in tablets of dicalcium phosphate or lactose. T h e method of size reduction of the dyed powder did not significantly affect the fading rate.