Stability of ascorbic acid in a liquid multivitamin emulsion containing sodium fluoride
✍ Scribed by James E. Tingstad; Lee H. Macdonald; Peter D. Meister
- Publisher
- John Wiley and Sons
- Year
- 1963
- Tongue
- English
- Weight
- 643 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The kinetics of the thermal oxidative nonphotolytic degradation of ascorbic acid ib a liquid multivitamin emulsion containing sodium fluoride have been studied. The vitamin appears to degrade initially by a pseudo zero-order reaction, but other evidence indicates that the true order of the reaction is closer to one. The reaction rate increases rapidly as the pH rises from 3.2 to 3.8, and it is this pH effect which probably causes the reaction to appear zero-order in its initial stages. By use of the Arrhenius e uation, data obtained from high temperature studies have been used to predict she# life at room temperature. Factors affecting the accuracy of the predictions are discussed. Sodium fluoride does not a preciably affect the stability of ascorbic acid in this preparation, but a reaction getween sodium fluoride and glass, producing a precipitate (NazSiFe), has been observed.
N THE development of new pharmaceutical