Constitutive activity and ligand-depende
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BjΓΆrn WindshΓΌgel; Antti Poso
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Article
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2011
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John Wiley and Sons
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English
β 434 KB
## Abstract The constitutive androstane receptor (CAR) possesses, unlike most other nuclear receptors, a pronounced basal activity __in vitro__ whose structural basis is still not fully understood. Using comparative molecular dynamics simulations of CAR Xβray crystal structures, we evaluated the mo