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Stability and Activity of Mesophilic Subtilisin E and Its Thermophilic Homolog: Insights from Molecular Dynamics Simulations

✍ Scribed by Colombo, Giorgio; Merz, Kenneth M.


Book ID
120008255
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
202 KB
Volume
121
Category
Article
ISSN
0002-7863

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## Abstract The constitutive androstane receptor (CAR) possesses, unlike most other nuclear receptors, a pronounced basal activity __in vitro__ whose structural basis is still not fully understood. Using comparative molecular dynamics simulations of CAR X‐ray crystal structures, we evaluated the mo