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Stabilisation of interferons by defensive reversible denaturation

✍ Scribed by STEWART, WILLIAM E.; DE CLERCQ, ERIK; DE SOMER, PIERRE

Book ID
109690573
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
214 KB
Volume
249
Category
Article
ISSN
0028-0836

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It has been shown that interferon-y (IFN-y) loses activity after acid treatment and this property can be used to distinguish it from other types of interferons. Therefore, reversibility of acid denaturation of IFN-y was examined using the recombinant human protein. The fluorescence spectra showed th