๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

SSRIs: Well tolerated treatment for depression

โœ Scribed by S. A. Montgomery; A. Roberts

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
411 KB
Volume
9
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

A clinical trial database which extends to 4126 depressed patients treated with paroxetine, 1954 patients on active control, and 625 placebo patients was analysed to assess the safety of treatment with paroxetine. A total of 451 patients included in the database were exposed to paroxetine for periods of one or more years. Paroxetine was generally better tolerated than comparator antidepressants with significantly fewer discontinuations due to adverse events. In particular, paroxetine was seen to be less likely to be associated with the development of seizures or manic episodes and appears to have a protective effect on the emergence of suicidal thoughts.

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