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SRY function in sex determination

✍ Scribed by Yen-Shan Chen; Michael A. Weiss

Book ID
116978246
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
38 KB
Volume
344
Category
Article
ISSN
0012-1606

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Description and functional implications
Description and functional implications of a novel mutation in the sex-determining gene SRY
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The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique. An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein. The affected tyrosine residue loca

SRY and Sex Determination in Mammals
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Interactions between SRY and SOX genes i
Interactions between SRY and SOX genes in mammalian sex determination
✍ Jennifer A. Marshall Graves πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 61 KB

The SRY gene on the mammalian Y chromosome undoubtedly acts to determine testis, but it is still quite unclear how. It was originally supposed that SRY acts directly to activate other genes in the testis-determining pathway. This paper presents an alternative hypothesis that SRY functions indirectly