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SREBPs suppress IRS-2-mediated insulin signalling in the liver

✍ Scribed by Ide, Tomohiro; Shimano, Hitoshi; Yahagi, Naoya; Matsuzaka, Takashi; Nakakuki, Masanori; Yamamoto, Takashi; Nakagawa, Yoshimi; Takahashi, Akimitsu; Suzuki, Hiroaki; Sone, Hirohito


Book ID
109912249
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
250 KB
Volume
6
Category
Article
ISSN
1465-7392

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To assess the role of insulin action and inaction in the liver, immortalized hepatocyte cell lines have been generated from insulin receptor substrate (IRS)-2 ؊/؊ and wild-type mice. Using this model, we have recently demonstrated that the lack of IRS-2 in neonatal hepatocytes resulted in insulin re