IRS-2 mediates the antiapoptotic effect
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Angela M. Valverde; Isabel Fabregat; Deborah J. Burks; Morris F. White; Manuel B
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Article
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2004
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John Wiley and Sons
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English
β 627 KB
To assess the role of insulin action and inaction in the liver, immortalized hepatocyte cell lines have been generated from insulin receptor substrate (IRS)-2 Ψ/Ψ and wild-type mice. Using this model, we have recently demonstrated that the lack of IRS-2 in neonatal hepatocytes resulted in insulin re