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SREBP-1c regulates glucose-stimulated hepatic clusterin expression

โœ Scribed by Gukhan Kim; Geun Hyang Kim; Gyun-Sik Oh; Jin Yoon; Hae Won Kim; Min-Seon Kim; Seung-Whan Kim

Book ID
116301742
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
342 KB
Volume
408
Category
Article
ISSN
0006-291X

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## Abstract Impairment of glucoseโ€stimulated insulin secretion (GSIS) caused by glucolipotoxicity is an essential feature in type 2 diabetes mellitus (T2DM). Palmitate and eicosapentaenoate (EPA), because of their lipotoxicity and protection effect, were found to impair or restore the GSIS in beta