Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia

Protein phosphatase 2A–negative regulati

Protein phosphatase 2A–negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia

✍ Jie Zhao; Hui-wen Wu; Yun-jiao Chen; He-ping Tian; Li-xin Li; Xiao Han; Jun Guo 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 600 KB

## Abstract Extracellular‐signal‐regulated kinase (ERK) undergoes rapid inactivation following the intense activation evoked by cerebral ischemia and reperfusion. However, the precise mechanism of this inactivation has not been elucidated. To investigate how phosphatases regulate the ERK cascade fo