D45 is the major transmembrane tyrosine phosphatase of the immune system and is highly expressed by all hematopoietic cells 1 . The best described role for CD45 is in antigen receptor signal transduction. In this case, the phosphatase activity of CD45 appears to be required for activation of Src-fam
Src family kinases: Regulation of their activities, levels and identification of new pathways
β Scribed by Evan Ingley
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 599 KB
- Volume
- 1784
- Category
- Article
- ISSN
- 1570-9639
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Dedifferentiation, a process by which differentiated cells become mesenchymalβlike proliferating cells, is the first step in renal epithelium repair and occurs in vivo after acute kidney injury and in vitro in primary culture. However, the underlying mechanism remains poorly understood.
## Abstract Chemical transmitters released from astrocytes, termed gliotransmitters, modulate synaptic transmission and neuronal function. Using astrocyteβspecific inducible transgenic mice (dnSNARE mice), we have demonstrated that inhibiting gliotransmission leads to reduced activation of adenosin