Src family kinases and HER2 interactions in human breast cancer cell growth and survival
โ Scribed by Belsches-Jablonski, Allison P; Biscardi, Jacqueline S; Peavy, Dena R; Tice, David A; Romney, Davis A; Parsons, Sarah J
- Book ID
- 110064500
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 229 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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In C3H/10T1/2 murine fibroblasts, overexpression of both c-Src and the human epidermal growth factor (EGF) receptor 1 (HER1) is required for detection of stable complexes between the two molecules and results in hyperactivation of the receptor and synergistic increases in tumor formation in nude mic
## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFโ1 receptor (IGFโ1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFโ7 cells engineered to o