## Abstract Cancer cells that develop resistance to chemotherapeutic agents are a major clinical obstacle in the successful treatment of breast cancer. Acquired cancer chemoresistance is a multifactorial phenomenon, involving various mechanisms and processes. Recent studies suggest that chemoresist
โฆ LIBER โฆ
Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib
โ Scribed by De Luca, Antonella; D'Alessio, Amelia; Gallo, Marianna; Maiello, Monica; Bode, Ann; Normanno, Nicola
- Book ID
- 126000708
- Publisher
- Landes Bioscience
- Year
- 2013
- Tongue
- English
- Weight
- 658 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1538-4101
- DOI
- 10.4161/cc.26899
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## Abstract We investigated the role of the MEK/MAPK pathway in the sensitivity/resistance of breast carcinoma cells to the EGFR tyrosine kinase inhibitor gefitinib (IRESSA). We assessed the effects of gefitinib on the growth of three breast cancer cell lines that showed high (SKโBrโ3; IC~50~ 4 ยตM)