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Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells

✍ Scribed by Jose G. Trevino; Michael J. Gray; Steffan T. Nawrocki; Justin M. Summy; Donald P. Lesslie; Douglas B. Evans; Tomi K. Sawyer; William C. Shakespeare; Stephanie S. Watowich; Paul J. Chiao; David J. McConkey; Gary E. Gallick

Book ID: 106337717
Publisher: Springer
Year: 2006
Tongue: English
Weight: 250 KB
Volume: 9
Category: Article
ISSN: 0969-6970
DOI: 10.1007/s10456-006-9038-9

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in