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SR59230A blocks β3-adrenoceptor-linked modulation of uncoupling protein-1 and leptin in rat brown adipocytes

✍ Scribed by Cristina Tonello; Laura Dioni; Luca Briscini; Enzo Nisoli; Michele O Carruba


Book ID
114016416
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
272 KB
Volume
352
Category
Article
ISSN
0014-2999

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Fetal brown adipocytes expressed uncoupling protein 1 (UCP1) mRNA, this expression being blunted throughout culture for 24 h in a serum-free medium. At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1