Square root of time dependence of matrix formulations with low drug content
✍ Scribed by Hatem Fessi; J.-P. Marty; F. Puisieux; J. T. Carstensen
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 381 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
tonine (20), and fusarenon-X (13). One explanation for this is that pep-tidy1 tRNA or methionyl tRNA lowers affinity binding of drug to ribosome (21). Daphnoretin effectively blocked peptidyl transferase activity of the elongation process. The magnitude of inhibition of protein synthesis is of a sufficient degree to account for the cessation of cell growth. It has been reported previously that daphnoretin suppresses DNA synthesis with an IDm = 0.194 mM (5). The present studies show that daphnoretin only suppresses protein and DNA synthesis in the Ehrlich ascites carcinoma cells, the only tumor screen in which daphnoretin demonstrated antineoplastic activity at 3-12 mg/kg/day. Protein and DNA synthesis of whole cells was not suppressed in normal mouse tissue, e.g., brain, kidney, and lung; but there was a moderate reduction of protein synthesis in the liver. Daphnoretin was isolated from Wikstroemia indica C . A. Mey (Thymelaeaceae), which has been used as a herbal remedy to treat human cancer, arthritis, syphilis, and whooping cough (22,23). This study of the mode of action of daphnoretin may explain some of the pharmacological properties of the plant.