Spurious isotope effects in enzymatic reactions with tritium labelled substrates

The neighboring group effect of fluorine

The neighboring group effect of fluorine in the tritium labeling of organic substrates with [Cp*(PMe3)IrMe(CH2Cl2)]+[BArf]−, a cationic iridium(III) complex

✍ Marc B. Skaddan; Robert G. Bergman 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 159 KB 👁 1 views

The cationic Ir(III) complex, [Cp\*(PMe 3 )IrMe(CH 2 Cl 2 )][BAr f ] (1, CpÃ ¼ Z 5 -C 5 Me 5 , BAr f ¼ MeBðC 6 F 5 Þ 3 ), has been shown to be a useful reagent in the tritium and deuterium labeling of organic substrates. During a recent reaction of 1 with a fluorinated molecule, we observed an unusu