[SpringerBriefs in Molecular Science] Nano-Bio Probe Design and Its Application for Biochemical Analysis || Metal-Nanoclusters-Based Luminescent Probe Design and Its Application

✍ Scribed by Ye, Bang-Ce; Zhang, Min; Yin, Bin-Cheng

• Book ID: 120245018
• Publisher: Springer Berlin Heidelberg
• Year: 2012
• Tongue: German
• Weight: 405 KB
• Edition: 2012
• Category: Article
• ISBN: 3642295436
• DOI: 10.1007/978-3-642-29543-0_5

✦ Synopsis

In this volume, Prof. Ye and his coworkers propose and review the concept of nano-bio probe design for biochemical analysis on the basis of their recent published works. A unique biochemical analysis technology based on fluorescence polarization enhanced by nanoparticles is described here with successful applications in environmental monitoring, rapid and sensitive sensing protease activity and high-throughput screening of inhibitors. Furthermore, they introduce a versatile molecular beacon (MB)-like probe for the multiplex sensing of targets such as sequence-specific DNA, protein, metal ions and small molecule compounds based on the self-assembled biomolecule-graphene conjugates. Besides, some colorimetric and luminescence probes utilizing metal nanoparticles for biochemical applications are also presented, such as chiral enantiomer discrimination and separation, environmental monitoring, clinic diagnosis and etc.