Spreading of an anchorage-dependent cell on a selectively ligand-coated substrate mediated by receptor-ligand binding
✍ Scribed by Ping Liu; Yong W. Zhang; Hanry Yu; Xin Zhang; Qian H. Cheng; Chun Lu; William Bonfield
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 336 KB
- Volume
- 91A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
A continuum model was proposed to simulate a biological cell adhering to a substrate surface domain with selectively coated ligands. Cell adhesion was modeled by a traction‐separation law depending on the receptor‐ligand distance and their densities. It was found that the obtained spreading patterns are consistent with published experimental data and that adhesion requires a nonuniform distribution of receptors at the spreading front with convex fronts requiring a much higher receptor density than concave fronts. Adhesion strength was also found to be more influential than adhesion energy on the spreading kinetics. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009