Spotlight on NKG2C and the human NK-cell response to CMV infection
β Scribed by Malmberg, Karl-Johan; Beziat, Vivien; Ljunggren, Hans-Gustaf
- Book ID
- 118758127
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 320 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IEβ1βspecific CD8^+^ T cells expressing IFNβΞ³, TNFβΞ±, and CD107a, alone or in combination, and NKG2C^+^ NK cells were
## Abstract Human cytomegalovirus (hCMV) infection is usually asymptomatic but may cause disease in immunocompromised hosts. It has been reported that hCMV infection may shape the NK cell receptor (NKR) repertoire in adult individuals, promoting a variable expansion of the CD94/NKG2C^+^ NK cell sub