Spontaneous stomach ulcer in genetically mast-cell depleted W/Wv mice
β Scribed by Shimada, M.; Kitamura, Y.; Yokoyama, M.; Miyano, Y.; Maeyama, K.; Yamatodani, A.; Takahashi, Y.; Tatsuta, M.
- Book ID
- 109717599
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 405 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/283662a0
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In spite of the apparent depletion of mast cells in tissues of mutant mice of W/W" genotype, cells with many features of mast cells do develop when bone marrow cells of W/W" mice are cultured in the presence of pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM). In order to resolve
Mice of genotype W/Wv have less than 1% of normal mast cells in the skin, stomach, and cecum. In order to further clarify the mechanism of this deficiency, we studied committed mast cell progenitors and multipotent progenitors, which are capable of mast cell differentiation in clonal culture. The re