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Spontaneous release of Fc receptor-like material from human lymphoblastoid cell lines

✍ Scribed by J.L. Molenaar; M. Van Galen; A.J. Hannema; W. Zeijlemaker; K.W. Pondman

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
748 KB
Volume
7
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

In the culture medium of some human lymphoblastoid cell lines material is released with the following properties: (a) hemagglutination reaction of IgG‐sensitized erythrocytes; (b) enhancement of precipitation of DNA‐anti‐DNA complexes; (c) inhibition of binding of Clq to immune complexes; (d) inhibition of immune complex binding to lymphocytes; (e) inhibition of antibody‐dependent lymphocytotoxicity The material is not identical with Clq or rheumatoid factor, it is heat resistant (30 min at 56 °C); the molecular weight is about 100 000 daltons and it is capable of inhibiting antibody production in vitro

It is suggested that this material consists of Fc receptors spontaneously shed from lymphocyte membranes.

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