Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: Implications for tardive dyskinesia

✍ Scribed by Dr. N. M. J. Rupniak; S. J. Tye; M. J. Steventon; S. Boyce; S. D. Iversen

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 517 KB
• Volume: 5
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870050410

✦ Synopsis

Abstract

We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03–0.24 mg/kg i.m.) or SCH23390 (0.05–0.2 mg/kg i.m.) but not by physostigmine (0.005–0.04 mg/kg i.m.) or scopolamine (0.0025–0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. Our findings indicate that neuroleptic‐induced tardive dyskinesias in most primate studies have not been clearly demonstrated.