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Spontaneous Hypoglycaemia in a Non-insulin-dependent Diabetes Mellitus Patient with Disseminated Pancreatic Carcinoma

✍ Scribed by Sturrock, N.D.C.; Selby, C.; Hosking, D.J.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
506 KB
Volume
14
Category
Article
ISSN
0742-3071

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✦ Synopsis

A 52-year-old-woman with non-insulin-dependent diabetes mellitus developed carcinoma of the pancreas and had a Whipple's resection performed. She required pancreatic exocrine supplements and insulin post-operatively. Five years later metastatic disease became apparent, and was accompanied by episodic spontaneous hypoglycaemia necessitating the cessation of insulin therapy. Hormonal analysis was performed, off insulin, at a time of hypoglycaemia (glucose 0.9 mmol l-1) and showed negligible insulin concentrations (< 2 mU l-1) but raised IGF-II together with low IGF-I concentrations (1.85 and 0.1 U ml-1, respectively). The association between diabetes and pancreatic carcinoma, and the pathogenesis of non-islet cell tumour induced hypoglycaemia (NICTH) are discussed.

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