𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Spontaneous gastroduodenal perforation in cancer patients receiving cytotoxic therapy

✍ Scribed by John L. Ricci; Alan D. M. Turnbull

Book ID
102440473
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
299 KB
Volume
41
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Spontaneous gastroduodenal perforation (SGDP) occurs in cancer patients receiving cytotoxic drugs, corticosteroids, or radiation therapy as primary or adjuvant treatment for their tumors. A retrospective review identified 12 patients from 1974 to 1987 at the Memorial Sloan-Kettering Cancer Center who underwent surgery for SGDP while receiving anticancer therapy.

There were five gastric and seven duodenal perforations. Vague abdominal pain was the most common symptom. Exploration was delayed in six patients because of an absence of physical findings. All patients received a Graham omental patch. The in-hospital operative mortality was 33%, with all major complications occurring in those that died. There were no prognostic indicators identified that would preoperatively predict outcome. Aggressive surgical intervention is advised in all patients who have a reasonable chance of worthwhile palliation if not cure.

πŸ“œ SIMILAR VOLUMES

Spontaneous gastroduodenal perforation i
Spontaneous gastroduodenal perforation in patients with cancer receiving chemotherapy and steroids. Report of four cases combining 5-fluorouracil infusion and cisplatin with antiemetics dexamethasone
✍ Chuang-Chi Liaw; Jen-Sheng Huang; Hung-Ming Wang; Cha-Hsiu Wang πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 355 KB

Background. Spontaneous gastroduodenal perforation is an uncommon but life-threatening complication of systemic chemotherapy and/or steroids. Here, the authors reported four cases of gastroduodenal perforation following combined chemotherapy with steroids. Methods. The chemotherapeutic regimens all

Interferon and spontaneous cytotoxicity
Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon
✍ Stefan Einhorn; Henric Blomgren; Hans Strander πŸ“‚ Article πŸ“… 1980 πŸ› John Wiley and Sons 🌐 French βš– 866 KB

## Abstract The effect of daily injections of 3 Γ— 10^6^ units of human leukocyte IF on the spontaneous cytotoxicity of peripheral lymphocytes was studied in 43 patients with a variety of diseases. An increase in spontaneous cytotoxicity was observed 12 to 24 h after the first IF injection with the