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Spontaneous factor VIII inhibitor occurring in association with chronic graft-versus-host disease

✍ Scribed by Christopher W. Seidler; Letha E. Mills; Mary E. D. Flowers; Keith M. Sullivan

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
363 KB
Volume
45
Category
Article
ISSN
0361-8609

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✦ Synopsis

M.E.D.F., K.M.S.)

The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequeiae. We report here the case of a patient who acquired a Factor Vlll inhibitor two years after an allogeneic bone marrow transplant for CML. This occurred in association with a flare of chronic graft versus host dlsease (GVDH). He responded to corticosteroid therapy. A review of autoimmune phenomena associated with chronic GVDH and the treatment of Factor Vlll Inhibitors is discussed.

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It has recently been shown that the Fas-Fas ligand (FasL) system may be one of the pathogeneses for acute graft-versus-host disease (GVHD), and it has been reported that serum soluble Fas ligand (sFasL) increases with the presence of acute GVHD. However, there is no report on a correlation between t