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Spontaneous degradation via diketopiperazine formation of peptides containing a tetrahydroisoquinoline-3-carboxylic acid residue in the 2-position of the peptide sequence

✍ Scribed by MARSDEN, BRIAN J. ;NGUYEN, THI M.-D. ;SCHILLER, PETER W.


Book ID
115099482
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
281 KB
Volume
41
Category
Article
ISSN
0367-8377

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Molecular Conformation and Packing of Pe
✍ Veldore Vidya Harini; Subrayashastry Aravinda; Rajkishor Rai; Narayanaswamy Sham 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

## Abstract Peptide β‐hairpin formation is facilitated by centrally positioned D‐Pro‐Xxx segments. The synthetic peptides Boc‐Leu‐Phe‐Val‐D‐Pro‐Ac~6~c‐Leu‐Phe‐Val‐OMe (**1**) and Boc‐Leu‐Phe‐Val‐D‐Pro‐Ac~8~c‐Leu‐Phe‐Val‐OMe (**2**) were synthesized in order to explore the role of bulky 1‐aminocyclo