Spontaneous crystalline-to-amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 1: Thermodynamics of spontaneous amorphization

Spontaneous crystalline-to-amorphous pha

Spontaneous crystalline-to-amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 2: Amorphization capacity and mechanisms of interaction

✍ Ken K. Qian; Steven L. Suib; Robin H. Bogner 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 503 KB

Amorphization of crystalline compounds using mesoporous media is a promising technique to improve the solubility and dissolution rate of poorly soluble compounds. The objective of this paper is to determine the capacity of amorphization and understand the mechanisms of phase transformation. Commerci