Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model

Molecular nature of mutations induced by

Molecular nature of mutations induced by a high dose of x-rays in spleen, liver, and brain of the lacZ-transgenic mouse

✍ T. Ono; H. Ikehata; S. Nakamura; Y. Saito; J. Komura; Y. Hosoi; K. Yamamoto 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 65 KB 👁 2 views

DNA sequences of 103 spontaneous mutants and 102 X-ray-induced mutants of the lacZ transgene from spleen, liver, and brain of the Muta™Mouse were examined and compared to elucidate characteristics of radiation-induced mutations in vivo. The radiation-induced mutants were isolated from genomic DNA of