## Abstract Our aim was to identify the biochemical defect responsible for the inability of highly growth autonomous human tumor cells to proliferate in culture medium devoid of methionine, but containing homocysteine and 5‐methyltetrahydrofolic acid. We have adopted the terms “homocysteine‐respons
✦ LIBER ✦
Spontaneous alteration in growth rates of two human melanoma xenografts. Concurrent changes in chemosensitivity
✍ Scribed by Fodstad, Øystein; Rofstad, Einar K.; Tveit, Kjell M.; Pihl, Alexander
- Book ID
- 123200048
- Publisher
- Elsevier Science
- Year
- 1983
- Weight
- 339 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0277-5379
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Fifteen percent of all human melanomas carry mutations in ras genes, the majority of which are located in codon 61 of the N-ras gene. However, the biological significance of these mutations is as yet unknown. In this study, we investigated the influence of N-ras oncogene products mutated in codon 61