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Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia

✍ Scribed by van der Burg, M; Poulsen, T S; Hunger, S P; Beverloo, H B; Smit, E M E; Vang-Nielsen, K; Langerak, A W; van Dongen, J J M

Book ID
110055866
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
382 KB
Volume
18
Category
Article
ISSN
0887-6924

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## Abstract HLA class I molecules serve the essential immunological function of presenting antigen to CD8+ T lymphocytes. Tumor cells may present tumor‐specific antigen to T cells via these molecules, but many tumors show a loss or down‐regulation of HLA class I expression and this may serve as an