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Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

โœ Scribed by Meyer, C; Burmeister, T; Strehl, S; Schneider, B; Hubert, D; Zach, O; Haas, O; Klingebiel, T; Dingermann, T; Marschalek, R


Book ID
110057058
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
118 KB
Volume
21
Category
Article
ISSN
0887-6924

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CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy-related chronic myelomonocytic leukemia. Subsequent re