Splice variants of the cell surface glycoprotein CD44 associated with metastatic tumour cells are expressed in normal tissues of humans and cynomolgus monkeys

The MHC class-II and CD44 molecules are

The MHC class-II and CD44 molecules are involved in the induction of tumour necrosis factor (TNF) gene expression by human monocytes stimulated with tumour cells

✍ Marek Zembala; Maciej Siedlar; Irena Ruggiero; Jerzy Wieckiewicz; Bozena Mytar; 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 801 KB

## Abstract Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/ molecular interactions leading to TNF gene expression in macrophages are unknown. The __in vitro__ system in which human blood monocytes are stimulated with human c