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Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant

✍ Scribed by Consuelo Funes; Faustino Garcia-Candel; Maria Juliana Majado; Consuelo González-García; Agueda Bas; Eduardo Salido; Jose M. Moraleda; Alfonso Morales

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
304 KB
Volume
25
Category
Article
ISSN
0733-2459

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✦ Synopsis

Abstract

Splenic rupture (SR) is a rare adverse event observed in patients treated with G‐CSF as a peripheral hematopoietic stem cell (PHSC) mobilizing agent, mostly in myeloma multiple and amiloidosis; to date, to our knowledge, it has not been previously described in plasma‐cell leukemia (PCL). We report a case of a woman with PCL, who presented a SR after PHSC mobilization with Cyclophosphamide+G‐CSF. The spleen removed showed hematopoietic foci and amiloid material. In the course of a second mobilization, 2 months after, the patient died from sepsis. We considered it important to report this case, in order to keep in mind the possibility of SR in patients with malignant gammopathy. J. Clin. Apheresis 25:223–225, 2010. © 2010 Wiley‐Liss, Inc.

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