Splenic involvement by blastic mantle cell lymphoma (Large cell/anaplastic variant) mimicking splenic marginal zone lymphoma
✍ Scribed by Mollejo, M.; Lloret, E.; Solares, J.; Bergua, J.M.; Mateo, M.; Piris, M.A.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 403 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
The most cases of splenic marginal zone lymphoma (SMZL) seem to respond favorably to splenectomy. The diagnosis of this lymphoma is mainly based on the recognition of a micronodular pattern of splenic involvement with marginal zone differentiation. However, it is possible to find so-called "marginal zone differentiation" in splenic involvement by other small B-cell lymphomas, particularly mantle cell lymphoma (MCL) and follicular lymphoma. We report a case of blastic MCL, large cell/anaplastic variant with a high level of clinical aggressiveness, showing biphasic cytology and a micronodular pattern which resembles SMZL. A single biopsy corresponding to this case shows two phases of tumoral progression in a MCL, a rare finding in MCL. In conclusion, the differential diagnosis of SMZL must take the possibility of a blastic MCL with biphasic cytology into account, as the case here. Am.