Splenic hemodynamics and decreased endothelial nitric oxide synthase in the spleen of rats with liver cirrhosis
β Scribed by Shohei Yamaguchi; Hirofumi Kawanaka; Daisuke Yoshida; Yoshihiko Maehara; Makoto Hashizume
- Book ID
- 116719087
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 826 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0024-3205
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In liver cirrhosis, down-regulation of endothelial nitric oxide synthase (eNOS) has been implicated as a cause of increased intrahepatic resistance. We investigated whether Rho-kinase activation is one of the molecular mechanisms involved in defective eNOS signaling in secondary biliary cirrhosis. L
Increased intrahepatic resistance in cirrhotic livers is in part caused by increased vascular tone. Several morphological abnormalities have been described in the sinusoidal endothelial cells of cirrhotic livers, but the functional impact of these abnormalities on the intrahepatic vascular tone has