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SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency

✍ Scribed by Shakhov, A N; Rubtsov, A V; Lyakhov, I G; Tumanov, A V; Nedospasov, S A


Book ID
110037209
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
340 KB
Volume
1
Category
Article
ISSN
1466-4879

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Lymphotoxin-alpha (LTalpha) was originally linked to delayed-type hypersensitivity and its production was later attributed to Th1, but not Th2 cells. Studies employing knockout mice demonstrated that LT signaling is essential for the development and functional compartmentalization of lymphoid tissue