Spiromarienonols A and B: Two New 7(8→9)abeo-Lanostane-Type Triterpene Lactones from the Stem Bark of Abies mariesii

✍ Scribed by Reiko Tanaka; Shun-ichi Wada; Hitoshi Aoki; Shunyo Matsunaga; Takao Yamori

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 191 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490011

✦ Synopsis

Abstract

Two new skeletal triterpene lactones, spiromarienonols A (1a) and B (2a), were isolated from the stem bark of Abies mariesii Masters (Pinaceae). Based on spectral data and biogenetic considerations, their unique three‐dimensional structures were determined to be (3__R__,7__S__,9__R__,23__R__)‐ (1a) and (3__R__,7__S__,9__S__,23__R__)‐3,7‐dihydroxy‐8‐oxo‐7(8→9)abeo‐lanost‐24‐eno‐26,23‐lactone (2a). Moreover, the potent activity of abiesenonic acid methyl ester (3) and abieslactone (4) against a disease‐oriented panel of 39 human cancer cell lines were investigated.