Spiroimine Toxins in Complex with Nicotinic Acetylcholine Receptors: Structure and Dynamics
✍ Scribed by Aráoz, Rómulo; Chabaud, Laurent; Guillou, Catherine; Molgó, Jordi; Iorga, Bogdan I.
- Book ID
- 122289810
- Publisher
- Biophysical Society
- Year
- 2011
- Tongue
- English
- Weight
- 57 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0006-3495
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## Abstract Nicotinic acetylcholine receptors (nAChRs), members of the Cys‐loop ligand‐gated ion channels (LGICs) superfamily, are involved in signal transduction upon binding of the neurotransmitter acetylcholine or exogenous ligands, such as nicotine. nAChRs are pentameric assemblies of homologou
Due to the complex mechanism of cation transport by neuronal nicotinic acetylcholine receptors (nAChR), potential ligands of these receptors must be characterized with respect to functional activity and corresponding subtype selectivity. Conventional radioactive binding assays have been established