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Spindle cell (Kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: Successful treatment with α-2A interferon

✍ Scribed by Deb, Giovanni; Jenkner, Alessandro; De Sio, Luigi; Boldrini, Renata; Bosman, Cesare; Standoli, Nicola; Donfrancesco, Alberto

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 424 KB
Volume: 28
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199705)28:5<358::aid-mpo6>3.0.co;2-g

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✦ Synopsis

A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increased capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach-Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon ␣-2a was given at the dosage of 3.000.000 U/m 2 , with resolution of the Kasabach-Merritt syndrome after three weeks and a 75% decrease of the tumor volume within three months of treatment. Med.

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Letter to the editor: “Spindle cell (kap

Letter to the editor: “Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: Successful treatment with α-2A interferon (Deb et al., Med. Pediatr. Oncol. 28:358–361)”

✍ Donfrancesco, Alberto 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views