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Spindle assembly checkpoint and centrosome abnormalities in oral cancer

✍ Scribed by Eswary Thirthagiri; C. Max Robinson; Suzy Huntley; Maria Davies; Lee Fah Yap; Stephen S. Prime; Ian C. Paterson


Book ID
116334534
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
967 KB
Volume
258
Category
Article
ISSN
0304-3835

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## Abstract Centrosome abnormalities have been found in various cancer types and are thought to be involved in early development of cancer and/or progression. The contribution of centrosome abnormalities to ovarian tumorigenesis has not been previously evaluated. We sought to determine whether cent

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## Abstract The centrosome is the main MT organizing center in animal cells, and has traditionally been regarded as essential for organization of the bipolar spindle that facilitates chromosome segregation during mitosis. Centrosomes are associated with the poles of the mitotic spindle, and several