Spinal cord long-term potentiation is attenuated by the NMDA-2B receptor antagonist Ro 25-6981

Frequency-Dependent Inhibition in the De

Frequency-Dependent Inhibition in the Dentate Gyrus Is Attenuated by the NMDA Receptor Blocker MK-801 at Doses That Do Not Yet Affect Long-Term Potentiation

✍ Kobi Rosenblum; Mouna Maroun; Gal Richter-Levin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

The dual impairment of both long-term potentiation (LTP) in the dentate gyrus and spatial memory by N-methyl-D-aspartate (NMDA) blockers such as 2-aminophosphonovaleric acid (APV) or dizocilpine (MK-801) is considered supportive evidence for the hypothesis that LTP-like mechanisms are involved in sp