Spina bifida, 677T→C mutation, and role of folate
β Scribed by R. de Franchis; G. Sebastio; C. Mandato; G. Andria; P. Mastroiacovo
- Book ID
- 118559882
- Publisher
- The Lancet
- Year
- 1995
- Tongue
- English
- Weight
- 218 KB
- Volume
- 346
- Category
- Article
- ISSN
- 0140-6736
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π SIMILAR VOLUMES
Defects of neural tube closure are among the most common of all human malformations. Epidemiological and genetic studies indicate that most of these defects are multifactorial in origin with genetic and environmental causes. Although periconceptional supplementation of the maternal diet with folic a
Spina bifida cystica (SB) is one of the most common and disabling of birth defects. Folic acid supplementation in mothers during the periconceptional period has been shown to prevent more than 70% of neural tube defects (NTD) including SB. However, the mechanism is unknown. We tested a series of mul