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Spin-label studies of membrane-associated denatured hemoglobin in normal and sickle cells

✍ Scribed by Pui-Wah Lau; Cynthia Hung; Kayoko Minakata; Elias Schwartz; Toshio Asakura

Book ID
115724230
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
586 KB
Volume
552
Category
Article
ISSN
0005-2736

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Hydroxyurea-induced denaturation of norm
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Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,