✦ LIBER ✦
Spin-echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte
✍ Scribed by J. Reglinski; W. E. Smith; R. D. Sturrock
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 378 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Human erythrocytes were subjected to oxidative stress using arsenicals. The study is a model for thiol-related redox processes observed in the etiology of diseases such as rheumatoid arthritis. Spin-echo NMR spectroscopy of the living cell was used to monitor the cellular biochemistry. Oxidation of glutathione and the first demonstrated response of ergothioneine to a chemical stimulus in a cell were observed. The reversible nature of the ergothioneine response is interpreted as an environmental rather than a chemical change.