Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells
โ Scribed by Victor E. Nava; John Peyton Hobson; Shvetha Murthy; Sheldon Milstien; Sarah Spiegel
- Book ID
- 115604408
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 449 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0014-4827
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I7f3-hydroxysteroid dehydrogenase (I 7HSD) type I converts the weakly active estrogen, estrone, into highly active estradiol. In addition to being essential for gonadal estradiol biosynthesis, the enzyme is also expressed in a significant proportion of breast tumors. In order to study the role of th
## Abstract It has been reported that estrogen receptor-positive MCF-7 cells express TauT, a Na+-dependent taurine transporter. However, there is a paucity of information relating to the characteristics of taurine transport in this human breast cancer cell line. Therefore, we have examined the char