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Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

✍ Scribed by Sung-Yun Cho; Hyo-Jeong Lee; Soo-Jin Jeong; Hyo-Jung Lee; Hyun-Seok Kim; Chang Yan Chen; Eun-Ok Lee; Sung-Hoon Kim


Book ID
111264842
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
415 KB
Volume
51
Category
Article
ISSN
0742-3098

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## Abstract We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing __in vitro,__ and caused downregulation of NF‐κB and APE1/Ref‐1. APE1/Ref‐1 functions as a redox activator of transcription factors, including NF‐κB and HIF‐1